Dr. Dennis Holmes

Academic training

  • Dr. Holmes is a 2003 graduate of the U.S.C. Breast Surgery Fellowship Training Program, one of the most progressive breast surgeon training programs in the U.S. Breast surgery fellowship training represents not only the highest level of commitment to excellence in breast cancer surgery but also dedication to understanding the roles of medical oncology, radiation oncology, plastic surgery, and other critical services in the management of breast cancer.

Professional experience

  • Dr. Holmes is an internationally renowned dedicated breast surgeon and cancer researcher who has held the position of Breast Center Medical Director at several hospitals in Los Angeles County.
  • Dr. Holmes served as Chief Breast Surgeon and Medical Director of the Los Angeles Center for Women’s Health and as Chief Breast Cancer Surgeon.
  • He also served in Breast Cancer Research Committee Co-Chair at the University of Southern California (U.S.C.) Kenneth Norris Comprehensive Cancer Center. 
  • He currently serves as National Co-Chair of the TARGIT U.S. Registry clinical trial.
  • Also he serves as National Principal Investigator of the FROST Trial, a clinical trial evaluating the use of cryoablation instead of surgery for the treatment of early stage breast cancer. In addition, he has been a pioneer in the field of minimally invasive breast surgery, including intraoperative radiotherapy, oncoplastic surgery, and lymph node-sparing surgery. 

Notable Achievements and Professional Associations

  • Dr. Holmes serves in the leadership of several national surgical societies and is a frequent lecturer at conferences internationally.
  • Dr. Holmes is a Fellow of the American College of Surgeons and currently serves as President of the TARGIT Collaborative Group, a national intraoperative radiotherapy research and education organization.
  • He was the Conference Program Chair of the 20th Annual Meeting of the American Society of Breast Surgeons, the nation’s largest breast surgeon society.
  • Dr. Holmes has gained worldwide acclaim for his pioneering research in intraoperative radiotherapy and cryoablation (tumor freezing).